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Restoration of p53 function leads to tumour regression in vivo

✍ Scribed by Ventura, Andrea; Kirsch, David G.; McLaughlin, Margaret E.; Tuveson, David A.; Grimm, Jan; Lintault, Laura; Newman, Jamie; Reczek, Elizabeth E.; Weissleder, Ralph; Jacks, Tyler


Book ID
109896479
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
776 KB
Volume
445
Category
Article
ISSN
0028-0836

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Restoration of p53 function: A new thera
✍ Naiara Beraza; Christian Trautwein πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 119 KB

Although cancer arises from a combination of mutations in oncogenes and tumour suppressor genes, the extent to which tumour suppressor gene loss is required for maintaining established tumours is poorly understood. p53 is an important tumour suppressor that acts to restrict proliferation in response