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Restoration of Growth Arrest by p16INK4, p21WAF1, pRB, and p53 Is Dependent on the Integrity of the Endogenous Cell-Cycle Control Pathways in Human Glioblastoma Cell Lines

โœ Scribed by Eugenia Costanzi-Strauss; Bryan E. Strauss; Robert K. Naviaux; Martin Haas


Book ID
115602845
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
459 KB
Volume
238
Category
Article
ISSN
0014-4827

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## Wild -type P16ICDKNZ MTSI) cDNA, directed by the cytomegalovirus (CMV) immediate early promoter, was transfected into RT4 and RTI I 2 bladder-carcinoma cell lines bearing a mutated endogenous P16ICDKNZ gene and lacking endogenous P 16lCDKN2 respectively. In both cases, only transfected clones w