Responsiveness to endocrine manipulations in breast cancer after “prophylactic” castration

✍ Scribed by Richard Kaufman; Philip Salem; Dr. Robert E. Wittes

• Book ID: 102439546
• Publisher: John Wiley and Sons
• Year: 1977
• Tongue: English
• Weight: 248 KB
• Volume: 9
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930090107

✦ Synopsis

Abstract

Two hundred and one cases of premenopausal women with breast cancer who underwent prophylactic castration with subsequent recurrence were reviewed to ascertain the degree of responsiveness of these patients to subsequent endocrine manipulation. We show that the standard endocrine manipulations, particularly the major ablations, retain a fair degree of activity in this group. There is a suggestion that the longer the castration‐recurrence interval, the higher the chance of a response, but the difference is significant only for osseous‐dominant disease. As in other patient groups, responders to subsequent endocrine manipulations live longer than nonresponders.