Responses of bone metabolism in the Eel (Anguilla anguilla) to injections of 1,25-dihydroxyvitamin D3
โ Scribed by E. Lopez; J. Peignoux-Deville; F. Lallier; K. W. Colston; I. Macintyre
- Publisher
- Springer
- Year
- 1976
- Tongue
- English
- Weight
- 872 KB
- Volume
- 22
- Category
- Article
- ISSN
- 1432-0827
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Differentiation and proliferation can be regulated in diverse cell types by 1,25-dihydroxyvitamin D 3 . These effects derive from modulation of gene expression mediated by the interaction of 1,25-dihydroxyvitamin D 3 with the vitamin D receptor (VDR). The VDR is one of the nuclear hormone receptors.
la,25-Dihydroxyvitamin D3 (1 a,25-(OH),D3) has been shown to increase cytosolic calcium and inositol triphosphate levels in rat osteosarcoma cells (ROS 17/23) and to increase nuclear calcium in these cells. To determine the mechanism(s) of Ia,25-(OH),D3-induced changes in nuclear calcium, the effect