The progression of human breast cancer is often associated with a loss of estrogen dependence for growth, a resistance to estrogen antagonists such as tamoxifen, and the metastatic spread of the disease to secondary sites. Cell lines developed from such advanced breast tumors are often metastatic in
Response to tamoxifen in estrogen receptor-poor metastatic breast cancer
β Scribed by Charles L. Vogel; Dawn R. East; Walter Voigt; Sharon Thomsen
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 547 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0008-543X
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Aminoglutethimide (AG) is an effective chemical ablative form of therapy for metastatic breast cancer in postmenopausal women. Estrogen receptor (ER) status in breast cancer is useful in predicting the response to the hormonal treatments. Of 134 postmenopausal metastatic breast cancer patients treat
Background. Influence of tamoxifen treatment on estrogen receptor (ER) and progesterone receptor (PR) levels in human breast cancer has not been fully elucidated in vivo. This problem was studied in 20 postmenopausal patients with ER-positive and PR-positive primary breast cancer. Each patient unde
A male patient with advanced breast cancer had no response to orchiectomy but subsequently enjoyed a 17-month partial response to tamoxifen 10 mg B.I.D. His tumor estrogen receptor (ER) protein was 555 fmol proteinhl cytosol. The potential role of ER determinations in the selection of therapy for ad