✦ LIBER ✦

Response to questions regarding conclusions reached in “Age dependence of femoral strength in white women and men”

✍ Scribed by Tony M Keaveny

Publisher: American Society for Bone and Mineral Research
Year: 2010
Tongue: English
Weight: 35 KB
Volume: 25
Category: Article
ISSN: 0884-0431
DOI: 10.1002/jbmr.231

No coin nor oath required. For personal study only.

✦ Synopsis

W e thank the Editors for the opportunity to assess Dr. Kaufman's analysis of our data and to further expound on the clinical relevance of our findings.

Dr. Kaufman is concerned that our analysis implicitly assumes that ''femoral strength as estimated by BCT is a much better quantity to estimate fracture risk than is aBMD.'' He also concludes that ''the implication that BCT provides superior information on bone strength and fracture risk at the proximal femur to that provided by aBMD is questionable at least based on the data provided in the article by Keaveny and colleagues.'' In fact, our analysis does not address assessment of fracture risk, nor does it assume that our BCT-derived estimates of femoral strength are better at fracture risk assessment than aBMD. We were careful in our conclusions not to broach comparatives of fracture risk assessment because we had no fracture outcome data available for this cohort at the time of our analysis. Instead, the focus of this article was on the more general issue of age-related trends for the population, highlighting differences in trends for aBMD and femoral strength, and not addressing superiority of one over the

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Questions regarding conclusions reached

Questions regarding conclusions reached in “Age dependence of femoral strength in white women and men”

✍ Jonathan J Kaufman 📂 Article 📅 2010 🏛 American Society for Bone and Mineral Research 🌐 English ⚖ 55 KB

This analysis does not address the issue of precision, but given the high levels of performance of present-day densitometers, this would not be expected to affect the fundamental results.