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Response to paclitaxel in adenoid cystic carcinoma of the salivary glands

✍ Scribed by Brian G. Till; Renato G. Martins

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
140 KB
Volume
30
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background.

Paclitaxel is not considered to be an active drug in adenoid cystic carcinoma (ACC) of the salivary glands. We report 2 consecutive cases of patients with ACC who responded to paclitaxel.

Methods.

The patients were: (1) a 58‐year‐old man with recurrent ACC who developed pulmonary metastases, had progressive disease after a good response to first‐line chemotherapy, and then achieved a partial response to weekly single‐ agent paclitaxel; and (2) a 46‐year‐old woman with extensive thoracic ACC metastases who achieved a significant response after 2 cycles of paclitaxel chemotherapy.

Results.

The first patient died of progressive disease approximately 4 months after completing paclitaxel therapy, and the second patient had disease control after 6 cycles of paclitaxel.

Conclusions.

Systemic weekly paclitaxel produced a significant response in 2 patients with ACC of the head and neck, and its use in this disease merits further study. Β© 2007 Wiley Periodicals, Inc. Head Neck, 2008

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