Response to methylphenidate is not influenced by DAT1 polymorphisms in a sample of Brazilian adult patients with ADHD
✍ Scribed by Verônica Contini; Marcelo M. Victor; Francine Z. C. Marques; Guilherme P. Bertuzzi; Carlos A. I. Salgado; Katiane L. Silva; Nyvia O. Sousa; Eugenio H. Grevet; Paulo Belmonte-de-Abreu; Claiton H. D. Bau
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 193 KB
- Volume
- 117
- Category
- Article
- ISSN
- 1435-1463
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## Abstract In this pharmacogenetic study in adults with ADHD (n = 42), a stratified analysis was performed of the association between response to methylphenidate (MPH), assessed under double‐blind conditions, and polymorphisms in the genes encoding the dopamine transporter, __SLC6A3 (DAT1)__, the
Although the efficacy of fluvastatin (HMG-CoA reductase inhibitor) in the treatment of primary hypercholesterolemia is well documented, a wide interindividual variation treatment response has been observed. We have studied the possible role of the AvaII (exon 13), HincII (exon 12), and PvuII (intron