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Response to measles revaccination among Bolivian school-aged children

✍ Scribed by A. Bartoloni; F.T. Cutts; P. Guglielmetti; D. Brown; M.L.Bianchi Bandinelli; H. Hurtado; M. Roselli


Book ID
104164759
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
449 KB
Volume
91
Category
Article
ISSN
0035-9203

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✦ Synopsis


The response to measles revaccination was evaluated in 1994 among 202 Bolivian school-aged children whose antibody levels were below 200 miu (milli-international units) by haemagglutination inhibition (HI) in a large-scale serosurvey conducted in Santa Cruz one year earlier. Of the 202 revaccinated children, 164 (82%) had seroconverted between the 1993 serosurvey and the pre-revaccination blood sample. A measles outbreak occurred in Santa Cruz 6 months before the revaccination. Among the seroconvertors, only 6% gave a history of measles, and 15% a history of contact with a case of measles. All 20 children with undetectable HI antibody pre-revaccination, and all 6 children with levels below 100 miu, seroconverted after revaccination. The geometric mean titres by HI at 4 weeks after revaccination were 20 18 miu (95% confidence limits [95% CL] 1143,3564) and 398 miu (95% CL 254,625) in the 2 groups, respectively. Six of 9 children with pre-revaccination antibody tin-es of 100-199 miu also seroconverted. No child demonstrated a measles-specific immunoglobulin M response. Among the 29 children who seroconverted and were followed up at one year after revaccination, 15 (52%) showed a fourfold or greater decline in antibody levels, which in 8 fell to levels below 200 miu. This study confirmed the observation that revaccination is successful in producing an antibody response in children with low or undetectable prerevaccination titres, but it also confirmed that vaccine-induced immunity wanes rapidly.


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