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Response to epirubicin in patients with superficial bladder cancer and expression of the topoisomerase II α and β genes

✍ Scribed by Sally L. Davies; Rick Popert; Malcolm Coptcoat; Ian D. Hickson; John R. W. Masters

Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
460 KB
Volume
65
Category
Article
ISSN
0020-7136

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✦ Synopsis

OX3 SOU; 2Departrnent of Urology, Kings Biopsies of superficial bladder cancer were analysed to study the relationship between response to epirubicin and the expression of the human topoisomerase II a and p genes. Tissue samples were obtained prior to treatment and a marker tumour was left in the bladder. Transcript levels of both genes were generally lower in biopsies taken following treatment failure. Levels of topoisomerase II mRNA were uniformly lower in tumour tissue than in biopsies of normal tissue.

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