Response to DNA-damaging agents in cultured cells from patients with X-linked duchenne muscular dystrophy phenotype: male DMD, female DMD, possible carriers
✍ Scribed by Laura Barsi; Giovanni Meola; Mariaelena Velicogna; Cristiana Bonifati; Anna Maria Fuhrman Conti; Guglielmo Scarlato
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 183 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0920-9069
No coin nor oath required. For personal study only.
✦ Synopsis
Using blood cultures the response to gamma ()') radiation was examined in a male DMD and his mother, in a female DMD and her mother and in a normal control. In a series of experiments chromosome aberrations were determined after 3 separate )'-irradiation close levels: 0, 150, 300 rads. The DMD patients showed a response to ionising radiations different from control, in fact the percentage of aberrations was lower than the control. In this preliminary study a slight difference between normal and possible carriers was also found.