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Response: The Mitochondrial β-Signal and Protein Sorting

✍ Scribed by Stephan Kutik; Diana Stojanovski; Thomas Becker; David A. Stroud; Lars Becker; Michael Meinecke; Vivien Krüger; Claudia Prinz; Bernard Guiard; Richard Wagner; Chris Meisinger; Nikolaus Pfanner; Nils Wiedemann

Book ID
116353976
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
64 KB
Volume
135
Category
Article
ISSN
0092-8674

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## Abstract In neurons, amyloid precursor protein (APP) is localized to the dendritic and axonal compartment. Changes in subcellular localization affect secretase cleavage of APP, altering the generation of Aβ, and presumably also its pathogenic features. It was reported that APP is sorted initiall