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Response of the whole bladder-urethra model (rabbit) to autonomic drugs

✍ Scribed by Alexa L. Chun; Alan J. Wein; Harcharan S. Gill; Dr Robert M. Levin

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
231 KB
Volume
9
Category
Article
ISSN
0733-2467

No coin nor oath required. For personal study only.

✦ Synopsis

To investigate the function of the bladder-urethra as a continuous unit we set up an in vitro whole bladder-urethra model (rabbit). We were able to measure the intravesical pressure at which saline infused into the bladder emptied via the urethra ("opening pressure"). Methoxamine added to the bath caused a significant increase in opening pressure, whereas phcntolaminc caused a significant decrease in opening pressure compared Lo controls.

Atropinc had no cffcct on opening pressure in the absence or presence o C methoxamine. 'Thus, it appears that the in vitro bladder-urethra unit has intrinsic alpha-adrenergic tonc that is of sufficient force to maintain an intravesical pressure of 7.0 cm H,O. and that this tone is not influenced by antagonism with the anticholinergie agcnt atropine.

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