𝔖 Bobbio Scriptorium
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Response of the toad,Xenopus laevis, to circulating antigens. II. Responses after splenectomy

✍ Scribed by Turner, Rodney J.

Book ID
102893437
Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
912 KB
Volume
183
Category
Article
ISSN
0022-104X

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✦ Synopsis

Abstract

It was demonstrated that the spleen cannot be the only site of antibody induction or formation in Xenopus laevis β€” even though cellular activity in response to circulating antigen is most evident in this organ β€” since serum antibody titres in splenectomized toads were comparable with those in sham‐operated animals after immunization with human gamma globulin (in adjuvant) or with sheep erythrocytes. This is of interest since the spleen appears to be the only lymphoid organ in X. laevis with any complexity of structural organization, the remaining foci consisting mainly of irregularly arranged lymphocytes. These experiments indicate that complex structural organization of lymphoreticular tissues may not be essential to immunological competence.

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