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Response of the adenosine phosphate pool level to changes in the catabolic pattern of Saccharomyces cerevisiae

✍ Scribed by M. D. Akbar; Pamela A. D. Rickard; F. J. Moss


Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
834 KB
Volume
16
Category
Article
ISSN
0006-3592

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✦ Synopsis


Changes in the catabolic pattern of Saccharornyces cerevisiae, growing in continuous culture, were effected by altering the glucose feed rate or the dissolved oxygen concentration. The cytochrome concentrations and the adenosine phosphate pool level of the yeast in a series of steady states and during three transitions were measured and compared with the glucose uptake rate (Qc), the respiration rate (QoJ, and the rate of ethariolic fermentation ( Q E ) .

Respiration was decreased at high glucose feed rates only if oxygen was low but cytochromes were glucose repressible at, both high and low oxygen concentrations. In the main, QE and the levels of ATP, ADP, arid AMP were decreased and cytochrome concentrations were elevated a t low QC values. No consistent relationship between any of the adenosine phosphate parameters and Qo, was discernible.

Evidence is presented for the concept that t,he QC direct,ly controls the adenosine phosphate pool level and that a relationship between the concentration of adenosine phosphate anhydride bonds and t,he adenosine phosphate level is constantly maintained.


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