๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Response of donor and recipient cells after transplantation of cells to the ligament and tendon

โœ Scribed by Kevin A. Hildebrand; Fengyan Jia; Savio L.-Y. Woo

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
675 KB
Volume
58
Category
Article
ISSN
1059-910X

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โœฆ Synopsis

The mechanical properties of healing ligaments and tendons are not comparable to those of normal tissue. To improve the quality of the ligament healing, therapeutic strategies include gene transfer or placement of mesenchymal stem cells at the healing site. Studies show that marker genes, growth factors, and antisense oligonucleotides can be delivered to both normal and healing ligaments and tendons by gene transfer. Cells with and without genetic modification have been successfully transplanted to ligaments and tendons and remain viable. Tendon healing can be improved using collagen gel implants seeded with autologous mesenchymal stem cells. Even though these early results are encouraging, more work is required regarding the response of the recipient site to donor cells or vectors.

๐Ÿ“œ SIMILAR VOLUMES

Response of the donor and recipient cell
Response of the donor and recipient cells in mesenchymal cell transplantation to cartilage defect
โœ Shigeyuki Wakitani; Tetsuya Yamamoto ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 778 KB

To facilitate the repair of articular cartilage defects, autologous mesenchymal cells from bone marrow or periosteum were transplanted in a rabbit model. Two weeks after the transplantation of the mesenchymal cells, the whole area of the original defect was occupied by cartilage. From the deep area