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Response of brain amino acid metabolism to ketosis

✍ Scribed by Marc Yudkoff; Yevgeny Daikhin; Ilana Nissim; Oksana Horyn; Adam Lazarow; Bohdan Luhovyy; Suzanne Wehrli; Itzhak Nissim


Book ID
116764663
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
205 KB
Volume
47
Category
Article
ISSN
0197-0186

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Brain amino acid metabolism and ketosis
✍ Marc Yudkoff; Yevgeny Daikhin; Ilana Nissim; Adam Lazarow; Itzhak Nissim πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 130 KB

## Abstract The relationship between ketosis and brain amino acid metabolism was studied in mice that consumed a ketogenic diet (>90% of calories as lipid). After 3 days on the diet the blood concentration of 3‐OH‐butyrate was ∼5 mmol/l (control = 0.06–0.1 mmol/l). In forebrain and cerebellum the c

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The synthesis of brain glutamate requires an amino group donor that is efficiently transported into the brain and that is readily transaminated. The branchedchain amino acids (BCAA), particularly leucine, play this important role. The uptake of leucine across the blood-brain barrier is faster than a