✦ LIBER ✦

Response of astrocytes and oligodendrocytes to injury

✍ Scribed by Yong, V. Wee

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 247 KB
Volume: 4
Category: Article
ISSN: 1080-4013
DOI: 10.1002/(sici)1098-2779(1998)4:3<193::aid-mrdd7>3.0.co;2-p

No coin nor oath required. For personal study only.

✦ Synopsis

Injury to the adult central nervous system (CNS) elicits a characteristic response of astrocytes in a process called reactive astrogliosis. The functions of reactive astrocytes remain unclear, and evidence is presented that these cells may serve to limit further damage and to promote regeneration, albeit in a failed attempt. To enhance the regenerative role of reactive astrocytes, the identification of the molecules that produce astrogliosis would be useful. Mediators of astrogliosis likely include inflammatory cytokines that can also affect CNS recovery in a direct manner. The perinatal brain, unlike the adult CNS, often does not undergo astrogliosis following insults unless certain conditions are fulfilled; these conditions include the activation of microglia and the production of inflammatory cytokines in the perinatal CNS. Finally, the reaction of oligodendrocytes to injury, and the facilitatory role of astrocytes in promoting oligodendrocyte recovery, are discussed.

1998 Wiley-Liss, Inc.

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