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Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras

✍ Scribed by Lauchle, Jennifer O.; Kim, Doris; Le, Doan T.; Akagi, Keiko; Crone, Michael; Krisman, Kimberly; Warner, Kegan; Bonifas, Jeannette M.; Li, Qing; Coakley, Kristen M.


Book ID
109898385
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
587 KB
Volume
461
Category
Article
ISSN
0028-0836

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## Abstract Active Ras contributes to the malignant phenotype of glioblastoma multiforme. Recent studies showed that the Ras inhibitor farnesyl thiosalicylic acid downregulates the transcription factor hypoxia‐inducible factor‐1Ξ±, causing shutdown of glycolysis in U87 glioblastoma cells. Farnesyl t