Respiratory stimulation and generation of superoxide radicals in Pseudomonas aeruginosa by fungal naphthoquinones
โ Scribed by H. Haraguchi; Kazumi Yokoyama; Shingo Oike; Masakazu Ito; Hiroshi Nozaki
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 102 KB
- Volume
- 167
- Category
- Article
- ISSN
- 0302-8933
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The aromatic thiol, thiophenol, is readily autoxidized at neutral pH in a reaction which generates superoxide radical and hydrogen peroxide. The oxidation product, diphenyl disulphide, may be reduced back to thiophenol by glutathione and in the presence of an excess of the latter thiol a reduction/a
## Objective: To investigate the role of intercellular adhesion molecule 1 (icam-1) and beta2 integrins in the production of superoxide (o2-) by c1q-stimulated human polymorphonuclear leukocytes (pmn). ## Methods: Pmn were pretreated with f(ab')2 fragments of monoclonal antibodies (mab) that bloc