✦ LIBER ✦

Respiratory oscillations in yeast: mitochondrial reactive oxygen species, apoptosis and time; a hypothesis

✍ Scribed by David Lloyd; Katey M. Lemar; L.Eshantha J. Salgado; Timothy M. Gould; Douglas B. Murray

Book ID: 104443560
Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 510 KB
Volume: 3
Category: Article
ISSN: 1567-1356
DOI: 10.1016/s1567-1356(03)00071-0

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✦ Synopsis

Oscillatory metabolic activities occur more widely than is generally realised; detectability requires observation over extended times of single yeast cells or synchrony of individuals to provide a coherent population. Where oscillations in intracellular metabolite concentrations are observed, the phenomenon has been ascribed to sloppy control, energetic optimisation, signalling, temporal compartmentation of incompatible reactions, or timekeeping functions. Here we emphasise the consequences of respiratory oscillations as a source of mitochondrially generated reactive O(2) metabolites. Temporal co-ordination of intracellular activities necessitates a time base. This is provided by an ultradian clock, and one result of its long-term operation is cyclic energisation of mitochondria, and thereby the generation of deleterious free radical species. Our hypothesis is that unrepaired cellular constituents and components (especially mitochondria) eventually lead to cellular senescence and apoptosis when a finite number of respiratory cycles has occurred.

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