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Respiratory function in mice lacking or overexpressing the prion protein

✍ Scribed by Eliane Boudinot; Patrick Tremblay; Jean Champagnat; Arthur S. Foutz


Book ID
117472428
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
156 KB
Volume
323
Category
Article
ISSN
0304-3940

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Peripheral nerves of mutant mice deficient for peripheral myelin protein 22 (PMP22) or connexin32 (Cx32) display similar pathologies as observed in hereditary human peripheral neuropathies. Mice lacking PMP22 develop focal hypermyelination followed by myelin degeneration and axonal atrophy. Cx32-def