Pharmacokinetic changes of M1, M2, M3 an
โ
Yun J. Choi; Hee J. Lee; Jong W. Kwon; Won B. Kim; Junnick Yang; Myung G. Lee
๐
Article
๐
1998
๐
John Wiley and Sons
๐
English
โ 208 KB
๐ 2 views
The pharmacokinetics of M1 -M4, the metabolites of a new anthracycline antineoplastic agent, DA-125, were compared after intravenous (IV) administration of DA-125, 15 mg kg -1 , to rats pretreated with enzyme inducers, such as phenobarbital (PBT, n =14) and 3-methylcholanthrene (MCT, n= 15), or enzy