𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Respective roles of hypoxia and halothane metabolism in halothane-induced liver injury in rats

✍ Scribed by Hitoshi Hatano; Fumio Nomura; Kunihiko Ohnishi; Toshihiko Iijima; Akira Hayasaka; Shinji Iida; Hirofumi Koen; Kunio Okuda

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
447 KB
Volume
5
Category
Article
ISSN
0270-9139

No coin nor oath required. For personal study only.

✦ Synopsis

To evaluate the respective roles of halothane metabolism and hypoxia in rats with halothane hepatotoxicity, experiments were designed with special reference to blood gas. After pretreatment with phenobarbital (80 mg per kg., i.p.) for four consecutive days, rats were exposed to 1.0% halothane under a mildly hypoxic condition (FiOz = 14%) for 2 hr. Since halothane anesthesia caused significant decrease in PaOz levels, rats exposed to a highly hypoxic atmosphere (Fi02 =

πŸ“œ SIMILAR VOLUMES

Effects of anticonvulsant agents on halo
Effects of anticonvulsant agents on halothane-induced liver injury in human subjects and experimental animals
✍ Fumio Nomura; Hitoshi Hatano; Kunihiko Ohnishi; Bunshiro Akikusa; Kunio Okuda πŸ“‚ Article πŸ“… 1986 πŸ› John Wiley and Sons 🌐 English βš– 560 KB

In order to evaluate the clinical implication of experimental studies on halothane-induced liver damage in phenobarbital-treated rats, we studied the clinical records of 315 consecutive patients who underwent brain surgery with halothane anesthesia. After exclusion of subjects with a history of alco

Hypoxia and CCI4-induced liver injury, b
Hypoxia and CCI4-induced liver injury, but not acidosis, impair metabolism of cysteinyl leukotrienes in perfused rat liver
✍ Matthias Wettstein; Wolfgang Gerok; Prof. Dr. Dieter HΓ€ussinger πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 796 KB

Uptake, metabolism and biliary elimination of infused cysteinyl leukotrienes were investigated in single-pass perfused rat liver. Hypoxia did not impair uptake of infused [3H]leukotriene C4, but inhibited biliary excretion of radioactivity by about 50% compared with normoxic control experiments. In

Impaired bile flow and disordered hepati
Impaired bile flow and disordered hepatic calcium homeostasis are early features of halothane-induced liver injury in guinea pigs
✍ L Frost; J Mahoney; J Field; G C Farrell πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 232 KB

To characterize the early events in liver injury pro-23:80-86.) duced by halothane, experiments were performed in genetically susceptible guinea pigs 19 hours after halothane exposure. Serum bile acid concentrations were Many studies have addressed the relationships befourfold increased in halothane

Role of the Liver in Endotoxin-Induced H
Role of the Liver in Endotoxin-Induced Hyperinsulinemia and Hyperglucagonemia in Rats
✍ Robert P. Cornell πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 570 KB

The intravenous administration of bacterial endotoxin to fasted rats elicited basal portal and systemic venous hyperinsulinemia and hyperglucagonemia. Enhanced pancreatic secretion of insulin and glucagon was implied by the elevated portal venous hormonal levels. Elevated insulin and glucagon levels

Opposite roles of neutrophils and macrop
Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen-induced acute liver injury
✍ Yuko Ishida; Toshikazu Kondo; Akihiko Kimura; Kouichi Tsuneyama; Tatsunori Takay πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 501 KB

## Abstract Neutrophils and macrophages infiltrate after acetaminophen (APAP)‐induced liver injury starts to develop. However, their precise roles still remain elusive. In untreated and control IgG‐treated wild‐type (WT) mice, intraperitoneal APAP administration (750 mg/kg) caused liver injury incl