Resorbable Antibiotic Coatings for Bone Substitutes and Implantable Devices

✍ Scribed by S. Vogt; K.-D. Kühn; U. Gopp; M. Schnabelrauch

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 231 KB
• Volume: 36
• Category: Article
• ISSN: 0933-5137
• DOI: 10.1002/mawe.200500963

✦ Synopsis

Antibiotic delivery systems based on biodegradable coatings have found considerable interest for the prophylaxis and local therapy of biomaterial-related infections. In this study sparingly watersoluble gentamicin salts have been prepared and tested as biodegradable antibiotic-releasing coating systems. Using the coating systems, homogeneous, well adhering films can be produced on various implant materials, like ceramics, glasses or metals surfaces, with different surface morphologies. The in vitro release profiles of the antibiotic coating systems were characterized by an initial burst release followed by a sustained release of small antibiotic amounts up to several weeks. It was found that the in vitro release, especially in the initial phase, can be modulated by the ratio between highly water-soluble gentamicin salts and sparingly soluble ones in the coating. Coating systems of the same type as described for gentamicin are available from a wide range of antibiotics differing in structure and mechanism of antibacterial action. Based on these results, the developed antibiotic coatings offer new perspectives to prevent and treat biomaterial-related infections.