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Resolution of the identity of the Ca2+-antagonist receptor in skeletal muscle

✍ Scribed by Pal L. Vaghy; Edward McKenna; Kiyoshi Itagaki; Arnold Schwartz

Book ID
119112121
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
840 KB
Volume
9
Category
Article
ISSN
0165-6147

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Tritiated analogues of the Ca2+ channel blockers such as [3H] PN200-110, [3H] verapamil and [3H] diltiazem have been used to identify and isolate Ca2+ antagonist receptors. The Ca2+ antagonist binding sites were solubilized from skeletal muscle transverse tubules with the detergent CHAPS and purifie