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Resolution of optical isomers by chiral high-performance liquid chromatography: Separation of dihydrodiols and tetrahydrodiols of benzo[a]pyrene and benz[a]anthracene

โœ Scribed by Henri B. Weems; Shen K. Yang

Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
483 KB
Volume
125
Category
Article
ISSN
0003-2697

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โœฆ Synopsis

Enantiomers of several underivatized dihydrodiols and tetrahydrodiols of benzo[a]pyrene and benz[a]anthracene have been resolved with high-performance liquid chromatography using a commercially available column packed with a o-3,5-dinitrobenzoylphenylglycine derivative of aminopropyl silica gel. Separation of optical isomers was confirmed by ultravioletvisible absorption and circular dichroism spectral analyses. This simple method has been applied to the determination of optical purity of two dihydrodiol metabolites formed from the in vitro incubation of 1 I-methylbenz[a]anthracene by rat liver microsomes.

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