Resolution of neutrophilic inflammation by H2O2 in antigen-induced arthritis
✍ Scribed by Fernando Lopes; Fernanda M. Coelho; Vivian V. Costa; Érica L. M. Vieira; Lirlândia P. Sousa; Tarcília A. Silva; Leda Q. Vieira; Mauro M. Teixeira; Vanessa Pinho
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 644 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0004-3591
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## Abstract ## Objective Annexin 1 (Anx‐1) is a putative mediator of the antiinflammatory actions of glucocorticoids (GCs). This study investigated the role of Anx‐1 in experimental arthritis and in GC‐mediated inhibition of inflammation, using antigen‐induced arthritis (AIA) in Anx‐1 knockout (An
A sensitive luminol-dependent chemiluminescence assay for H2O2 was developed for the indirect determination of the transient changes in NADPH oxidase activity associated with the respiratory burst of human neutrophils. A relatively large, controlled amount of horseradish peroxidase was used in combi