Resolution of complex, proton-n.m.r. spectra of carbohydrate derivatives by using “tilted”, two-dimensional J spectra

✍ Scribed by Laurance D. Hall; Gareth A. Morris; Subramaniam Sukumar

• Publisher: Elsevier Science
• Year: 1979
• Tongue: English
• Weight: 228 KB
• Volume: 76
• Category: Article
• ISSN: 0008-6215
• DOI: 10.1016/0008-6215(79)80037-3

✦ Synopsis

We have previously demonstratedf3 some of the diagnostic potential, in organic chemistry, of proton two-dimensional (2D) n.m.r. spectroscopy, using displays derived directly from the flrequencydomain data-matrix obtained by doubl$.Fourier-transformation of spin-echo, time-domain data. As is clear from the studies of Ernst and coworkers4*, the interpretation of 2D J spectra is simplified if the 2D spectrum is first tilted through 4S"-'& frequency space, id we have now written a computer routine to effect this '!tilt?'. Its use is 'illustrated here with results for uridine (1) and'@ p-D-xylopyranose (2), both in DzO solution. The fundamental, proton, 2D J spectroscopy experiment has been thoroughly described elsewhere' --9 ; it yields a spectrum in two frequency-dimensi0nsf.t and fz, signal dispersion iri fi reflecting the normal, proton spectrum, and, in fi , multiplet structure only.