(Re)Solution of a Protein Fold Without Solution
โ Scribed by Dr. Perdita E. Barran
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 474 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
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Pioneering experiments by Frauenfelder and collaborators have shown that the ligands of iron CO, O in heme proteins 2 ) ลฝ ) such as myoglobin and hemoglobin, when photo-dissociated at temperatures up to about T for example, T s 160 K for . ลฝ . MbCO in glycerol-water exhibit an anomalous power-law,
## Abstract Simple theoretical models are presented to illustrate the effects of spatial confinement and macromolecular crowding on the equilibria and rates of protein folding and binding. Confinement is expected to significantly stabilize the folded state, but for crowding only a marginal effect o