Resolution during total synthesis of reserpine

✍ Scribed by L. Novák; J.O. Jílek; B. Kakáč; M. Protiva

• Book ID: 104235091
• Publisher: Elsevier Science
• Year: 1959
• Tongue: French
• Weight: 180 KB
• Volume: 1
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)82761-1

✦ Synopsis

IE their brilliant total eynthesis, Woodward et al 1 -. carried out the resolution in the final stage by meens of (+)-camphor-lo-sulfonio aoid and obtained (-)-reserpine, identical with the natural produot. With reepeot to technical preparation, placing the resolution at the end of a long aynthesie ie uufavourable. Therefore, the work of Vellua et., 2 rho performed the resolution in the stage lo-hexahydro-1-naphthoio acid -using the the synthesis in the opening phases, ie a This method, however, ia Woodward'a variant.4 In order to achieve impracticable in the very advantageous second the resolution at the stage of the hydro*g la&one of ois-5-hydroxy-8-0x0-1,4,5,8,9, -3 firat Woodward's variant of considerable improvement. Is le5 we prepared its acid phthalate Ib (m.p.