Resolution and some properties of (1,1′)-bi(dibenzofuranyl)-2,2′-diol (BIFOL)
✍ Scribed by Arjan E. Sollewijn Gelpke; Jan Fraanje; Kees Goubitz; Henk Schenk; Henk Hiemstra
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 641 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The synthesis and resolution of 3,3%-bis(benzyloxy)-1,1%-binaphthalene-2,2%-diol 1 is described. A diastereomeric mixture of 7 (derived from (±)-1 and Boc-Ala-OH) was separated using crystallization and column chromatography.
Corynebacterium C12 epoxide hydrolase transforms (±)-l-methyl-l,2-epoxycyclohexane 1 to the (I-S, 2-S)-l-methylcyclohexane-l,2-diol 2 leaving the (1-S, 2-R)epoxide 3 unchanged. The diol 2 is converted to the the (l-R, 2-S )-epoxide 4 by sulfonationring closure. A one pot combination of Corynebacteri