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Resolution and chromatographic configuration analysis of 2-hydroxy fatty acids

✍ Scribed by K.-A. Karlsson; I. Pascher

Publisher
Elsevier Science
Year
1974
Tongue
English
Weight
444 KB
Volume
12
Category
Article
ISSN
0009-3084

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✦ Synopsis

2-Hydroxyoctadecanoic acid was resolved into D and L isomers as salts of 1-phenylethylamine enantiomers The diastereomers of phenylethylamides of 2-hydroxy fatty acids and the eorresponalng derivatives with protected hydroxy group (aeetyl, methyl, trifluoro-acetyl, tfimethylsilyl) are well separated by thin-layer or gas-liquid chromatography. This allows a simple microanalysis of configuration and optical purity of 2-hydroxy fatty acids. With this method 2-hydroxy fatty acids from sphingomyelin of the honey-bee were shown to belong exclusively to the D series.

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