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Resistance to TRAIL-induced apoptosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase-8 expression

✍ Scribed by Grotzer, Michael A; Eggert, Angelika; Zuzak, Tycho J; Janss, Anna J; Marwaha, Sunil; Wiewrodt, Barbara R; Ikegaki, Naohiko; Brodeur, Garrett M; Phillips, Peter C


Book ID
118676904
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
246 KB
Volume
19
Category
Article
ISSN
0950-9232

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Resistance to apoptosis correlates with
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Apoptosis induced by effector cells of the immune system or by cytotoxic drugs is a main mechanism mediating the prevention or elimination of tumoral cells. For instance, the human T-cell leukemia Jurkat is sensitive to Fas-induced apoptosis and to activation-induced cell death (AICD), and the promo