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Resistance to Leishmania major infection correlates with the induction of nitric oxide synthase in murine macrophages

✍ Scribed by Foo Y. Liew; Yun Li; David Moss; Clive Parkinson; Mark V. Rogers; Salvador Moncada


Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
532 KB
Volume
21
Category
Article
ISSN
0014-2980

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We recently reported that the infection of macrophages with Leishmania major led to the release of type 1 interferons (IFN- Β§ / g ). Moreover, at day 1 of infection of mice with L. major, IFN- Β§ / g was required for the expression of type 2 (inducible) NO synthase (NOS2 or iNOS) which, however, was