Resistance to CD95 (Apo-1/Fas)-mediated apoptosis is a typical feature of breast cancer cells. Recent studies identified deleterious mutations of the CD95 gene not only in a variety of B cell lymphomas but also in a number of solid tumor entities. Therefore, we amplified and sequenced selected regio
✦ LIBER ✦
Resistance to CD95-mediated apoptosis in breast cancer is not due to somatic mutation of the CD95 gene
✍ Scribed by C Moers, M Müschen, MW Beckmann, P Mallmann
- Book ID
- 120700893
- Publisher
- BioMed Central
- Year
- 2001
- Tongue
- English
- Weight
- 293 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1465-5411
- DOI
- 10.1186/bcr407
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## Abstract It is important for more effective gene therapies to clarify the mechanisms by which cDNA integrated into cells can maintain or lose its function __in vivo__. We evaluated genetic and epigenetic events leading to alternation of the introduced CD95 (Fas/Apo‐1) gene as a model of gene the
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