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Resistance to Antitumor Agent-Induced Apoptosis in a Mutant of Human Myeloid Leukemia U937 Cells

✍ Scribed by Shiro Kataoka; Mikihiko Naito; Akihiro Tomida; Takashi Tsuruo

Book ID
115601891
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
469 KB
Volume
215
Category
Article
ISSN
0014-4827

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Tumor necrosis factor-a (TNF-a) is a cytokine that induces apoptosis in various cell systems by binding to the TNF receptor (TNFR). To study TNF-a-induced apoptosis, we isolated and characterized a novel TNF-a-resistant variant, U937/ TNF clone UA, from human monocytic leukemia U937 cells. The UA ce