Resistance to Activated Protein C: A Common Inherited Cause of Venous Thrombosis
β Scribed by David L. Gillespie; Lee R. Carrington; John H. Griffin; Barbara M. Alving
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 426 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0890-5096
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Four hundred and ninety-three consecutive patients referred for arterial or venous thrombosis were screened for congenital and acquired abnormalities of blood coagulation predisposing to thrombosis, and were compared to 341 age-and sex-matched controls. The aim of the study was to determine the prev
## BACKGROUND. Thromboembolic events are well recognized complications of can-
Hereditary predisposition to thrombosis due to activated protein C resistance (APCR) has been attributed to a missense mutation in the factor V gene at nucleotide 1691 (G to A), causing replacement of arginine at codon 506 with glutamine. Using an RFLP-PCR assay to detect this mutation, we measured