Resistance of recent measles virus wild-type isolates to antibody-mediated neutralization by vaccinees with antibody
✍ Scribed by Matthias Klingele; Heike K. Hartter; Festus Adu; Wim Ammerlaan; Wole Ikusika; Claude P. Muller
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 172 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0146-6615
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✦ Synopsis
The neutralization capacity of sera from Luxembourgian adolescent vaccinees and from Nigerian women with measles-induced immunity to a number of measles virus strains was compared. Although both cohorts were matched for their hemagglutination inhibition and standard neutralization titers, 12 of the 22 late convalescent sera, and only 6 of 24 vaccinees neutralized all viruses. Similarly, only 2 of 20 viruses were not neutralized by at least 75% of late convalescent sera, in comparison to 10 of 20 viruses that resisted neutralization by at least 75% of the vaccinees. The more resistant viruses were not limited to a certain clade. One Nigerian virus was resistant to neutralization by 30% of the late convalescent women and by 75% of vaccinees. These results suggest that qualitative differences in neutralizing antibodies may reduce further protection of infants by passively acquired immunity against wild-type viruses when vaccinated girls become mothers.