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Resistance of fibroblasts and hematopoietic cells to ecotropic murine leukemia virus infection; an Akvr-1R gene effect

✍ Scribed by Suraiya Rasheed; Murray B. Gardner

Publisher: John Wiley and Sons
Year: 1983
Tongue: French
Weight: 740 KB
Volume: 31
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910310415

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✦ Synopsis

Abstract

A gene named Akvr‐1segregates as a dominant allele in California wild mice (LC). Unlike Fv‐1 and Fv‐2 restriction alleles, the Akvr‐1confers resistance to replication of all ecotropic (N‐, B‐, and NB‐tropic) murine leukemia viruses (MuLV‐E) and prevents endogenous AKR virus‐induced lymphoma/leukemia in F~1~ hybrids of AKR × LC. We have tested fibroblasts and hematopoietic cells from mice of defined Akvr‐1 genotypes for in vitro susceptibility to various MuLV infections. Our results indicated a dominant in vitro resistance of exogenously MuLV‐E infected cells carrying Akvr‐1^R^ allele although resistance was stronger in the homozygous cells than in the heterozygous cells. Moreover, resistance of cells to virus replication was not abrogated by high multiplicities of infection or by growth stimulation of hematopoietic cultures by various T‐ or B‐cell‐responsive mitogenic agents.

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## Abstract A murine sarcoma virus‐transformed S+L—3T3FL cell line has previously been shown to be equally susceptible to infection with both N‐ and B‐tropic variants of murine leukemia virus, unlike all other mouse cells so far described (Krontiris et al., 1973). Transformed S+L—‐BALB/3T3 and S+L‐