Resistance of cultured hepatoma cells to copper toxicity. Purification and characterization of the hepatoma metallothionein
โ Scribed by Freedman, Jonathan H.; Peisach, J.
- Book ID
- 122875503
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 803 KB
- Volume
- 992
- Category
- Article
- ISSN
- 0304-4165
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The molecular basis for increased metallothionein concentrations in copperresistant hepatoma cells was examined. The copper-resistant cell line HAC, , , , which is maintained in 600 k m copper, had increased steady-state mRNA levels for both the metallothionein-1 (MT-1) and the metallothionein-2 (MT
## Abstract The addition of calf serum to culture medium alters the biological response of Morris hepatoma 7777 (MH) cells to autocrine growth factors isolated from conditioned medium of the investigated cells. Acetic acid (AA) extract obtained from conditioned medium of MH cells showed a change in