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Residue-Level Interrogation of Macromolecular Crowding Effects on Protein Stability

✍ Scribed by Charlton, Lisa M.; Barnes, Christopher O.; Li, Conggang; Orans, Jillian; Young, Gregory B.; Pielak, Gary J.

Book ID: 121224854
Publisher: American Chemical Society
Year: 2008
Tongue: English
Weight: 257 KB
Volume: 130
Category: Article
ISSN: 0002-7863
DOI: 10.1021/ja8005995

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## Abstract In cells, proteins execute specific tasks in crowded environments; these environments influence their stability and dynamics. Similarly, for an enzyme molecule encapsulated in an inorganic cavity as in biosensors or biocatalysts, confinement or excluded volume plays an important role in