Residual solvents determination in drug products by static headspace-gas chromatography
โ Scribed by C. C. Camarasu
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 567 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0009-5893
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๐ SIMILAR VOLUMES
## Abstract Static headspace (HS) sampling has been commonly used to test for volatile organic chemicals, usually referred to as residual solvents (RS) in pharmaceuticals. If the sample is not soluble in water, organic solvents are used. However, these seriously reduce the sensitivity in the determ
## Abstract A specific, sensitive, and simple method for the quantitation of residual methanol, 2โpropanol, 2โbutanol, 2โmethoxyโ1โethanol, 1โchloroโ3โmethoxyโ2โpropanol, 3โchloroโ2โmethoxyโ1โpropanol, and 1,3โdimethoxyโ2โpropanol in two nonโionic Xโray contrast media, has been developed. The heads
## Abstract Static headspace GC, a simple, clean technique which is easily automated, appears to be a good approach to the determination of solvent residues in pharmaceutical preparations. The feasibility of this approach has been studied with an automated system. Data is presented for the solvent