Residual effects on actual car driving of evening dosing of chlorpheniramine 8 and 12 mg when used with terfenadine 60 mg in the morning
✍ Scribed by A. Vermeeren; J. G. Ramaekers; C. J. Van Leeuwen; J. F. O'Hanlon
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 163 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0885-6222
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✦ Synopsis
The study was conducted according to a 4-way, observer-and subject-blind, cross-over design. Its purpose was to compare the repeated dose eects on actual driving performance of the following: the combination of chlorpheniramine 8 and 12 mg, in sustained release formulations, administered at bedtime and terfenadine 60 mg the following morning; ¯urazepam 30 mg at bedtime and placebo the following morning; and, placebo at both times. Subjects were 24 healthy female volunteers. Drug eects were assessed in two driving tests (highway driving and carfollowing) in the morning of the third treatment day. Results show no signi®cant dierences in driving performance between both chlorpheniramine/terfenadine treatments and placebo. Flurazepam signi®cantly impaired driving in both tests.