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Resident enteric microbiota and CD8+ T cells shape the abundance of marginal zone B cells

✍ Scribed by Bo Wei; Thomas T. Su; Harnisha Dalwadi; Robert P. Stephan; Daisuke Fujiwara; Tiffany T. Huang; Sarah Brewer; Lindy Chen; Moshe Arditi; James Borneman; David J. Rawlings; Jonathan Braun


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
864 KB
Volume
38
Category
Article
ISSN
0014-2980

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B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the accumulation of mature-appearing clonal B cells exhibiting coexpression of CD5 and CD23. In addition to the accumulation of neoplastic B cells, numerous T-cell abnormalities also occur in B-CLL patients. In this study, the presence,