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Reshaping human antibodies for therapy

✍ Scribed by Riechmann, Lutz; Clark, Michael; Waldmann, Herman; Winter, Greg

Book ID
109752624
Publisher
Nature Publishing Group
Year
1988
Tongue
English
Weight
535 KB
Volume
332
Category
Article
ISSN
0028-0836

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## Abstract Trifunctional antibodies are able to redirect T cells and FcΞ³ receptor^+^ accessory immune cells to tumor targets. The simultaneous activation of these different classes of effector cells results in efficient killing of the tumor cells by different mechanisms such as phagocytosis and pe