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Resetting the histone code at CDKN2A in HNSCC by inhibition of DNA methylation

โœ Scribed by Coombes, Madelene M; Briggs, Katrina L; Bone, James R; Clayman, Gary L; El-Naggar, Adel K; Dent, Sharon YR


Book ID
110068134
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
212 KB
Volume
22
Category
Article
ISSN
0950-9232

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The expression of several cancer-related genes has been reported to be silenced by DNA methylation of their promoter region. 5-Aza-2-deoxycytidine (5-AZA-CdR), a potent and specific inhibitor of DNA methylation, can reactivate the in vitro expression of these genes. In future clinical trials in tumo