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Reserpine and the suppression of both edema formation and cellular infiltrate of the contact sensitivity reaction in the mouse

✍ Scribed by O. Bäck; O. Groth

Book ID
104766734
Publisher
Springer-Verlag
Year
1983
Tongue
English
Weight
220 KB
Volume
275
Category
Article
ISSN
0340-3696

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✦ Synopsis

Reserpine treatment in doses of 1.0 and 5.0 mg/kg body weight, given 6 h before antigen challenge significantly suppresses the contact sensitivity reaction to picryl chloride in sensitized mice. The suppression involves both the edema formation, measured as ear swelling, and the accumulation of inflammatory cells at the test site. This is probably mediated through inhibition of the release of vasoactive amines from local mast cells.

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✍ G. L. Asherson; M. Zembala 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 English ⚖ 413 KB

## Abstract Passive transfer of contact sensitivity and suppression of contact sensitivity by lymph node cells is abolished by treatment with anti‐Θ serum and complement. In contrast, both these forms of passive transfer by peritoneal exudate cells resist treatment with anti‐Θ serum but are abolish