## Abstract The synthesis of a series of compounds resembling in some respects the reserpine alkaloid and containing a β‐phenylethylamine configuration substituted at the phenyl group with alkoxyl groups is described.
Reserpine analogues IV. Hydroxy-β-phenylethylamine derivatives
✍ Scribed by T. Kralt; W. J. Asma; H. D. Moed
- Book ID
- 104586371
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 496 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0165-0513
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✦ Synopsis
Abstract
The synthesis of a series of compounds resembling in some respects the reserpine alkaloid and containing a β‐phenylethylamine configuration substituted at the phenylgroup with hydroxyl groups is described.
📜 SIMILAR VOLUMES
## Abstract The synthesis of a series of compounds resembling in some respects the alkaloid reserpine is described. The compounds are β‐indolylethylamine (tryptamine) derivatives.
Methyl 5-carboxamido-4-hydroxy-3(B-D-ribofuranosyl)-2-thiophene carboxylate 2a and the corresponding 2.,5-thiophene dicarboxamide 2b, two new analogues of-the antiviral compound pyrazofurin, were synthesized: A base mediated condensation method with dimethyl thiodiacetate and methyl 2(2,3,5r tri-0-~
^)-3-Iso-19,20-dehydro-b-yohimbine has been converted into epiallo-yohimbines and, via a novel regioand stereoselective hydration, into the 18R-hydroxy derivative, an analogue of deserpidine. Its 11-methoxy derivative, also prepared from secologanin, is a potential precursor for a reserpine analogue