Research and development report: Production of fine particulate ultra high molecular weight poly(ethylene) for biological response studies
✍ Scribed by H. D. Leigh; P. Taylor; A. Swaney; Prof. Jonathan Black
- Book ID
- 102290565
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1992
- Tongue
- English
- Weight
- 392 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1045-4861
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✦ Synopsis
Abstract
Interest in biological responses to particulate biomaterials has produced a need for well‐characterized submicron ultra high molecular weight poly(ethylene) (UHMWPE) debris. A new technique, cryogenic attrition, is described as well as a characterization of an initial ca. 65% submicron preparation of UHMWPE, termed grind S. Production of submicron particles from a common commercial medical grade of primary UHMWPE “grain” produces fractions with different densities, apparently reflecting the presence of crystalline and amorphous phases. Further process optimization and debris characterization is planned with eventual distribution of material as an interlaboratory comparison material for biological response experiments.